Objective To investigate the correlation between lifestyle and menopausal syndrome of females.Methods A multi-stage stratified cluster sampling method was used to randomly select 7 856 females aged 40-69 in Zhejiang Prov-ince for a questionnaire survey.Mantel-Haenszel test was used for ordered categorical variables,Kruskal-Wallis H test was used for disordered variables and multiple logistic aggression analysis were used to determine the correlation between lifestyle and menopausal syndrome and drawn ROC curve.Results Age was associated with menopause and menopausal syndrome(P<0.05).Passive smoking,drinking,tea drinking,physical exercise intensity,frequency of hair perming and dyeing were associated with menopausal syndrome(P<0.05).Older age(OR=1.103,95%CI:1.094-1.112),menopause(OR=4.011,95%CI:3.573-4.503),family members smoking(OR=1.346,95%CI:1.206-1.501),and passive smoking in the working environment(OR=1.432,95%CI:1.175-1.745)were risk factors for menopausal syndrome(P<0.05).Lower physical activity intensity(OR=0.881,95%CI:0.822-0.944)and low frequency of hair perming(OR=0.823,95%CI;0.774-0.876)were protective factors for menopausal syndrome(P<0.05).The area under the ROC curve for lifestyle-related factors predicting menopause-related symptoms was 0.731.Conclusion The lifestyle of females aged 40-69 in Zhejiang Province is correlated with menopausal syndrome.Lifestyle coaching is recom-mended for females to reduce or relieve menopausal syndrome.