Objective To investigate the association between serum vitamin D and vascular endothelial growth factor(VEGF)levels in late pregnancy and pre-eclampsia and fetal growth restriction(FGR),to provide a basis for clinical di-agnosis and management of pre-eclampsia and FGR.Methods The 124 patients with pre-eclampsia in the third trimes-ter of pregnancy from July 2020 to December 2022 at Zhoushan Maternal and Child Health Hospital were selected as the study group,including 38 patients with FGR.In addition,54 normal pregnant women in their third trimester of pregnancy from the same term as the control group.Serum 25-hydroxyvitamin D(25-OH-D)levels were measured by electrochemi-cal immunoassay,and the serum VEGF levels were measured by enzyme-linked immunosorbent assay.Results Serum 25-OH-D[(73.42±6.71)nmol/L]and VEGF[(412.31±35.24)pg/mL]in the study group were lower than in the control group[(94.78±5.25)nmol/L,(536.21±26.23)pg/mL,P＜0.05].Serum 25-OH-D[(69.20±5.96)nmol/L]and VEGF[(394.70±32.17)pg/mL]were lower in the FGR group than in the non-FGR group[(82.97± 7.28)nmol/L,(452.17±27.49)pg/mL,P＜0.05].Pearson analysis showed that 25-OH-D and VEGF were negatively correlated with pre-eclampsia and FGR(P＜0.05).In predicting pre-eclampsia and FGR,the sensitivity of 25-OH-D were 83.30％and 76.29％,and the specificity were 77.43％and 64.19％;VEGF had a sensitivity of 80.13％and 68.08％,and a specificity of 68.92％and 56.24％.25-OH-D and VEGF were independent risk factors for pre-eclampsia and FGR.Conclusion The decrease in serum 25-OH-D and VEGF levels in patients with pre-eclampsia and FGR in the third trimester of pregnancy is negatively correlated with the occurrence of pre-eclampsia and FGR and is a risk factor for pre-eclampsia and FGR.
关键词
妊娠晚期/子痫前期/25-羟维生素-D/血管内皮生长因子/胎儿生长受限
Key words
Late pregnancy/Pre-eclampsia/25-hydroxyvitamin D/Vascular endothelial growth factor/Fetal growth re-striction
维普
万方数据