Clinical study of Xiaoyong Qufu Shengji Decoction combined with thymosin α1 in the treatment of bronchodilation in stable stage of lung Qi deficiency type
Clinical study of Xiaoyong Qufu Shengji Decoction combined with thymosin α1 in the treatment of bronchodilation in stable stage of lung Qi deficiency type
Objective Based on the traditional Chinese medicine(TCM)theory of"treating the lung close to the tem-perature",the effect of Xiaoyong Qufu Shengji Decoction combined with thymosin α1 on the stable stage of bronchiectasis was discussed to provide evidence of clinical curative effect.Methods From January 2021 to January 2023,88 patients with lung Qi deficiency type bronchodilation admitted to Lishui Hospital of Traditional Chinese Medicine Affiliated to Zhe-jiang University of Chinese Medicine were selected and divided into control and study groups of 44 cases each by random number table method.On the basis of conventional symptomatic treatment,the control group was treated with thymosinα1,and the study group was treated with Xiaoyong Qufu Shengji Decoction combined with thymosin α1,all of which were continuously treated and observed for 8 weeks.The TCM syndrome score,lung function[percentage of forced expiratory volume in one second to expected value(FEV1％pred),ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)],T lymphocyte subsets[CD4+,CD8+,CD4+/CD8+]of the two groups were observed,and the efficacy and adverse reactions of the TCM syndrome were compared.Results After treatment,the scores for"cough"and"expectoration"and the total score for TCM syndrome were lower in the study group than in the control group(P＜0.05),and the total efficacy rate for TCM syndrome[90.91％(40/44)]was higher than that in the control group[72.73％(32/44),P＜0.05].After treatment,FEV1％pred,FEV1/FVC,CD4+,CD4+/CD8+in the study group were higher than those in the control group(P＜0.05)and CD8+were lower than those in the control group(P＜0.05).There was no significant difference in the rate of side effects between groups(P＞0.05).Conclusion Xiaoyong Qufu Shengji Decoction combined with thymosin α1 can completely relieve the clinical symptoms of bronchodilation of lung Qi deficiency type,improve lung function and immune function,and enhance clinical efficacy and safety.
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