Objective Analysis of the trends in the global disease burden of Parkinson's disease from 1990-2019 and to explore the impact of age,period,and cohort on the risk of developing the disease burden of Parkinson's disease.Meth-ods By collecting and analyzing the global disease burden of Parkinson's disease from 1990 to 2019,the Joinpoint re-gression model was used to analyze the trend of the disease burden of Parkinson's disease,and the age-period-cohort model(APC model)was used to analyze the age,period and cohort effects of the disease burden of Parkinson's disease.Results The global standard disability-adjusted life years(DALY)rate for Parkinson's disease showed no overall trend from 1990 to 2019(P＞0.05),the standard DALY rate(per 100 000 population)of males and females increased and decreased,respectively.The standard DALY rate of males increased from 102.86 to 106.44,with an annual average in-crease rate of 0.119％[average annual percentage change(AAPC)=0.119,t=2.559,P=0.010].The normalized DALY rate(per 100 000 population)in females decreased from 61.61 to 59.91,with an annual average rate of 0.097％(AAPC=-0.097,t=2.565,P=0.010).Results of the APC model showed that the age effect of DALY rate risk of PD increased first and then decreased with increasing age during 1990-2019(P＜0.05).The period effect increased with the increase of year(P＜0.05).The cohort effect decreased with the progression of the birth cohort(P＜0.05).Conclusion From 1990 to 2019,there was no change in the global disease burden of Parkinson's disease,Males showed an upward trend and females showed a downward trend.The risk of disease burden increased first and then de-creased with the increase of age,increased with the increase of years,and decreased with the increase of birth cohort.Prevention efforts should be strengthened in special groups such as the elderly.Reducing the future global burden of Par-kinson's disease.
关键词
帕金森病/疾病负担/年龄-时期-队列模型
Key words
Parkinson's disease/Burden of disease/Age-period-cohort model
万方数据