Objective The objective of this study is to investigate the correlation among serum vitamin D levels,cogni-tive function,and depressive mood in elderly individuals with mild cognitive impairment(MCI),aiming to establish a theoretical foundation for clinical intervention.Methods Between February 2023 and August 2023,a total of 315 sub-jects with MCI were screened from the elderly community population.Blood samples were collected to measure vitamin D levels,with 155 subjects categorized as vitamin D deficient group and 160 subjects categorized as normal group.A com-parative analysis was conducted to assess the general conditions of these two groups.Additionally,scores from the mini-mental state examination(MMSE),the Montreal cognitive assessment(MoCA),the geriatric depression scale(GDS),and centre for epidemiological studies depression scale(CES-D)were compared between the two groups.Results Com-pared with the normal group,the vitamin D deficient group exhibited significantly lower scores in immediate memory(9.01±1.41 vs.8.46±2.36),calculation(3.64±1.60 vs.3.20±1.76),memory[2.00(1.00,3.00)vs.2.00(1.00,2.00)],repeat[1.00(0.00,1.00)vs.1.00(0.00,1.00)],and three-step command(2.59±0.71 vs.2.28±0.90)of MMSE.The total score(25.10±3.05 vs.23.56±3.90),and language score of MoCA,as well as mem-ory and total score,were also significantly lower in the vitamin D deficient group(P＜0.05).Furthermore,the total score of CES-D in the vitamin D deficient group(13.10±4.12 vs.11.26±4.81)was significantly higher(P＜0.01).Correlation analysis revealed a positive association between vitamin D levels and overall cognitive function(P＜0.05),while serum vitamin D levels showed a negative correlation with depressive mood(P＜0.05).Conclusion Vitamin D level has been found to be associated with cognition and depression in individuals with MCI.
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