Objective The aim of this study was to compare the application effectiveness and safety of combined inhala-tion anesthesia and total intravenous anesthesia in pediatric cochlear implantation surgery.Methods A retrospective a-nalysis was conducted on 100 pediatric patients who underwent cochlear implantation surgery at Nanjing Tongren Hospital from May 2018 to March 2023.They were divided into two groups based on the different anesthesia methods:combined inhalation anesthesia(control group)and total intravenous anesthesia(study group).The differences between the two groups were compared in terms of general conditions,pre-and post-operative hemodynamics and bispectral index(BIS),postoperative immediate electrical impedance,postoperative restlessness and recovery time,postoperative oxidative stress levels,and adverse reactions.Results There were no significant difference in age,height,weight,anesthesia time,he-modynamic indexes(SBP,DBP,HR)and BIS index between the study group and the control group(P＞0.05).The immediate electrical impedance at the end of surgery in the study group was lower than that in the control group[low-fre-quency:(2.57±0.40)kΩ vs.(3.93±0.83)kΩ;high-frequency:(7.00±0.31)kΩ vs.(8.37±0.42)kΩ,P＜0.001].The postoperative sedation-agitation scale(RASS)and recovery time of the study group were lower than those of the control group(P＜0.001).There was significant difference in postoperative oxidative stress levels between the two groups(P＜0.001).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Total intravenous anesthesia is a safer and more effective approach compared to combined anesthe-sia for cochlear implantation surgery in children.Total intravenous anesthesia offers notable benefits in terms of intraoper-ative hemodynamics control,recovery time,oxidative stress levels,and postoperative impedance.Therefore,total intra-venous anesthesia should be considered as the primary option in clinical practice for cochlear implantation surgery in chil-dren.However,the selection of the anesthetic modality should be carefully evaluated,considering the unique needs for each patient and the experience of the anesthesia team.
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