Objective To investigate the relationship between serum Clq/tumor necrosis factor-related protein 9(CTRP9)and gestational diabetes mellitus(GDM)and its clinical significance.Methods A total of 35 patients with GDM and 37 pregnant women without the condition were enrolled.The general characteristics,glucose metabolism indi-cators,serum CTRP9 levels and other adipokine levels were compared between the two groups.In addition,a Pearson correlation analysis was conducted to examine the correlation between serum CTRP9,other cytokines and clinical indexes in pregnant women with GDM.Results The fasting plasma glucose(FPG),OGTT 1hPG,OGTT 2hPG,fasting insulin(FINS),HOMA-IR,interleukin-6(IL-6),leptin,tumor necrosis factor-α(TNF-α),and CTRP9 in the GDM group were higher than those in the control group(P＜0.05).The results of the Pearson correlation analysis indicated that ser-um CTRP9 was positively correlated with FPG,1hPG,2hPG,FINS,HOMA-IR,IL-6 and TNF-α(P＜0.05).The lo-gistic regression analysis showed that elevated HOMA-IR(OR=14.771,P=0.046)and CTRP9(OR=4.965,P=0.002)were independent risk factors for GDM.ROC analysis demonstrated that CTRP9 and HOMA-IR had areas under the curve of 0.914 and 0.822,respectively,for diagnosing GDM.The combined detection had an area under the curve of 0.943,indicating optimal diagnostic efficiency.Conclusion The serum CTRP9 level is elevated in GDM.Elevated se-rum CTRP9 level is an independent risk factor for GDM.Furthermore,the combination of serum CTRP9 and HOMA-IR was more efficient in screening for GDM.
Gestational diabetes mellitusC1q/tumor necrosis factor-related protein 9AdipokinesInsulin resistance
维普
万方数据
