Objective To investigate the survival prognosis of elderly patients with non-obstructive hypertrophic cardio-myopathy(nHCM),and to establish a nomogram based on cardiac magnetic resonance(CMR)parameters and clinical characteristics to predict the overall survival(OS)of patients with nHCM.Methods A total of 179 patients with nHCM admitted to the Cardiovascular Center of Suining Central Hospital and Nanchong Central Hospital from June 2015 to No-vember 2021 were retrospectively analyzed.Multivariate Cox regression analysis was used to determine the independent prognostic factors associated with OS and nomogram was drawn.The internal validation was performed by Bootstrap.Re-sults Multivariate Cox regression analysis showed that the prognostic factors were galectin-3(Gal-3),ventricular tachy-cardia,apical aneurysm,late gadolinium enhancement(LGE),exercise stress test.The Bootstrap correction value of c-index was 0.908(95％CI:0.869-0.947);The area under the curve of 1,3,and 5-year survival rate calculated by multi time point ROC curve were 0.907,0.935,and 0.921 for discrimination analysis.The calibration curve showed that the predicted estimated risk had good accuracy with the actual observation results.Conclusion The elevation of Gal-3,ventricular tachycardia,apical ventricular aneurysm,positive exercise stress test,and positive LGE based on CMR parameters are independent risk factors that affect the prognosis of elderly nHCM patients.The nomogram construc-ted based on the above indicators can be used to individualize the assessment of the prognosis of elderly nHCM patients.
关键词
非梗阻性肥厚型心肌病/心脏磁共振/诺莫图/预后
Key words
Non obstructive hypertrophic cardiomyopathy/Cardiac magnetic resonance/Nomogram/Prognosis
维普
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