Objective To retrospectively analyze the clinical characteristics of vaginal intraepithelial neoplasia(VaIN),and to evaluate the clinical effect of 5-aminolevulinic acid-based photodynamic therapy(ALA-PDT)in the treatment of VaIN.Methods The clinical data of 136 patients diagnosed with VaIN by colposcopic biopsy who underwent ALA-PDT at the First Affiliated Hospital of Bengbu Medical College from January 2019 to April 2022 were selected,and the clinical data of 65 patients who underwent CO2 laser therapy were selected.HPV and TCT were regularly checked in all patients.At the same time,colposcopic biopsy was performed to retrospectively analyze the clinical characteristics of VaIN,explore the clinical efficacy of ALA-PDT treatment of VaIN,and compare with CO2 laser treatment.Results A 12-month follow-up was performed after the end of treatment.At the last follow-up,85 cases(69.1％)in the ALA-PDT group and 32 ca-ses(51.6％)in the CO2 laser group achieved complete HPV clearance.The HPV clearance rate was compared between the two groups,and the difference was statistically significant(P＜0.05).During the follow-up,112 patients(82.4％)in the ALA-PDT group had complete clearance the lesions,5 patients(3.7％)had persistent disease,12 patients(8.8％)had partial remission,3 patients(2.2％)had progression,and 4 patients(2.9％)had recurrence.In the CO2 laser group,42 cases(64.6％)had complete remission,3 cases(4.6％)persisted,8 cases(12.3％)had partial re-mission,2 cases(3.1％)progressed,and 10 cases(15.4％)recurred.The overall complete remission rate of lesions in ALA-PDT group was higher than that in the CO2 laser group,the difference was statistically significant(P＜0.05),and the recurrence rate in the ALA-PDT group was lower than that in the CO2 laser group,the difference was statistically sig-nificant(P＜0.05).There were 6 cases(4.4％)of adverse reactions in the ALA-PDT group and 9 cases(13.8％)in the CO2 laser group.The incidence of adverse reactions was lower in the ALA-PDT group than in the CO2 laser group,and the difference was statistically significant(P＜O.05).Conclusion ALA-PDT treatment of VaIN lesions has a higher complete remission rate,can effectively eradicate HPV infection,has fewer side effects,low recurrence rate,and merits further clinical promotion.
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