Objective This study aims to examine the association between the triglycerides to HDL cholesterol(TG/HDL-C),cystatin C levels,and insulin resistance in pre-pregnancy women.Additionally,it seeks to investigate the cor-relation between TG/HDL-C and cystatin C with gestational diabetes mellitus(GDM).Methods A total of 198 preg-nant women at the Affiliated Hospital of West Anhui Health Vocational College from January 2020 to June 2022 were se-lected as the research objects.They were divided into two groups:the observation group(98 cases with GDM)and the control group(100 cases without GDM).General clinical data from both groups were collected and analyzed to explore the relationship between these data and GDM.Results There were no significant difference in education,family eco-nomic situation,diet control,exercise,smoking history,drinking history,waist circumference,SBP,DBP,FPG,ALT,AST,Cr,UA,TC,HDL-C,and LDL-C between the two groups(P＞0.05).However,but there were significant differ-ence in age,BMI,Cys-C,and LDL-C.Logistic regression analysis showed that advanced age,elevated serum Cys-C,and increased TG/HDL-C ratio were independent risk factors for GDM(P＜0.05),with corresponding OR of 1.111,3.190 and 3.970 respectively.ROC curve analysis demonstrated that TG/HDL-C ratio had an area under the Cys-C curve(AUC)of 0.820(P＜0.001),while Cys-C had an AUC of 0.667(P＜0.001).The combined detection of both parameters yielded an AUC of 0.848(P＜0.001),indicating better diagnostic efficiency compared to individual tests.Conclusion Pregnant women with high serum TG/HDL-C ratio and Cys-C levels prior to pregnancy are at a higher risk of GDM.These two indicators hold promise for risk assessment and prediction of GDM in pregnant women.
维普
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