Objective The traditional teaching mode of clinical practice medicine is usually oral teaching by the instruc-tor,and the knowledge flow is mainly one way transfer of"instructor-trainee",which has certain limitations.Based on the traditional teaching model,the problem-based teaching model(PBL)combined with case-based teaching model(CBL)was introduced to reform the teaching method,and the teaching effect was discussed.Methods A total of 50 in-terns in Urology,People's Hospital of Wuhan University from September 2019 to June 2022 were selected and divided in-to two groups according to the odd and even numbers of interns:experimental group and control group(25 persons each).The experimental group adopted the teaching mode of PBL combined with CBL for teaching urology clinical intern-ship teaching,while the control group followed the conventional teaching mode for internship training,the experimental group adopted an innovative approach.Results The results demonstrated that the experimental group achieved signifi-cantly higher scores in both the clinical thinking test[(44.54±3.75)points]and the total scores[(87.80±3.25)points]than the control group scores[(34.26±2.42)points,(78.28±4.03)points,P<0.001];And the students of the experimental group improve the learning efficiency,consolidate the external outside professional knowledge,improve the learning interest and strengthen their learning ability and participation,cultivate clinical thinking[23(92.0%),24(96.0%),23(92.0%),24(96.0%)]were better than those in the control group[17(68.0%),15(60.0%),16(64.0%),16(64.0%),P<0.05].There was no significant difference in satisfaction with improving learning eficiency[23(92.0%)in the experimental group and 22(88.0%)in the control group,P>0.05].Conclusion The teaching mode of PBL combined with CBL in urology clerkship improved the teaching effect and quality,which is worth practicing and promoting in clinical teaching work.