Objective To investigate the expression of circular RNA PRKCI(circPRKCI)and microrNA-545(miR-545)in colorectal cancer tissues and their effects on prognosis.Methods From March 2013 to April 2018,102 patients with colorectal cancer underwent surgical resection in Zhengzhou Seventh People's Hospital were collected.The expres-sion levels of circPRKCI and miR-545 in colorectal cancer patients with different clinicopathological characteristics were analyzed.The effects of circPRKCI and miR-545 expression levels on the prognosis of patients were analyzed by Cox re-gression and survival curve.Results The expression of circPRKCI was significantly up-regulated in colorectal cancer tissues compared to paracancer tissues(1.47±0.69 vs.0.82±0.42,t=8.644,P＜0.05).Conversely,miR-545 expres-sion was significantly down-regulated in colorectal cancer tissues(0.86±0.55 vs.1.60±0.66,t=8.908,P＜0.05).The expression of circPRKCI increased and the expression of miR-545 decreased in patients with lymph node metastasis and TNM stage Ⅲ-Ⅳ(P＜0.05).Furthermore,patients with high expression of circPRKCI and low expression of miR-545 exhibited poor prognosis(P＜0.05).Both circPRKCI and miR-545 were identified as independent risk factors for poor prognosis in patients with colorectal cancer,and their expression showed a negative correlation.Conclusion The expression of circPRKCI and miR-545 is related to the adverse pathological parameters and prognosis in patients with colorectal cancer,suggesting a potential regulatory role of circPRKCI in the progression of colorectal cancer involving miR-545.
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