Objective To summarize the experience in rehabilitation management in the first case of adult living donor liver transplantation in Anhui Province.Methods The doctor-nurse integrated group was established in the Department of Organ Transplantation,Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital of Anhui Medical Universi-ty in December 2021.The doctor-nurse integrated management consisted of precise care in three courses:preoperative e-valuation stage,perioperative period and domestic management period of both of the liver transplant donor and recipient.During the preoperative evaluation period of transplantation,comprehensive assessment and intervention of medical care integration were carried out from three aspects:anatomy,physiology and social psychology.The living donor liver trans-plantation must be especially approved from the senior ethics committee.A precise overall evaluation of both the donor and the recipient is a cornerstone in a successful living donor liver transplantation.In addition to routine perioperative care during the perioperative period,a good recovery of both the donor and the recipient is dependent on the following five aspects:adequate preoperative preparation,refined care in immunosuppressive drugs management,monitoring of trans-planted organ function,protective isolation in case of infection prevention,and optimization of rapid recovery management strategies.During the domestic care course,various nursing interventions were used to improve the self-efficacy level of the recipients,to encourage patients to adopt healthy behaviors,to optimize the postoperative examination process and to track the drug compliance by monitoring the blood drug concentration,counting tablet and collecting questionnaire sur-vey.Results Both donor and recipient underwent successful operations.The donor recovered well and was discharged from the hospital 11 day after operation and the recipient was discharged on the 18th day with satisfied recovery.The blood biomarkers of both the donor and the recipient indicated sufficient liver function.The plasma concentration of im-munosuppressants was maintained at an ideal level,and the remnant liver volume of both the donor and the recipient was appropriate.The follow-up was conducted intensively during the domestic care course.It turned out that both the donor and the recipient showed satisfied recovery 8 months after the operation.Conclusion Adult living donor liver transplan-tation requires close cooperation of the medical team,rigorous attitude,high-quality management,and precise treatment and nursing measures,so as to obtain a satisfactory prognosis for both the donor and the recipient.