Objective To explore the relationship between whole blood iron level and hyperuricemia in Kailuan study population,and to provide evidence for the early prevention of hyperuricemia.Methods A cross-sectional study was conducted in 3 579 employees and retirees of Kailuan Group who participated in the health examination and completed the whole blood iron test in Linxi Hospital,Majiagou Hospital and Jinggezhuang Hospital from August,2017 to May,2018.According to the level of serum uric acid,the subjects were divided into normal serum uric acid group(n=2 983)and hyperuricemia group(n=596).Multivariate logistic regression model was used to analyze the association between whole blood iron(divided into Q1 to Q3 three subgroups according to tertiles)and hyperuricemia,and the effect of different a-ges on the association between whole blood iron and hyperuricemia was analyzed.Results The whole blood iron in hype-ruricemia group[(464.73±104.05)mg/L]was significantly higher than that in normal serum uric acid group[(420.96±109.60)mg/L,P＜0.001].Multivariate logistic regression analysis showed that after adjusting for other confounding factors,compared with the whole blood iron Q1 group,the OR value(95％CI)of hyperuricemia in the whole blood iron Q3 group was 1.989(1.487-2.661).In the subjects aged＜60 years,the OR value(95％CI)of hy-peruricemia in the whole blood iron Q3 group was 2.304(1.539-3.450),while which was 1.269(0.818-1.969)in the subjects aged ≥60 years.In sensitivity analysis,compared with the whole blood iron QI group,the OR value(95％CI)of hyperuricemia in the whole blood iron Q3 group was 2.018(1.499-2.716).Conclusion Higher whole blood iron level is associated with an increased risk of hyperuricemia,especially in people younger than 60 years old.
关键词
血尿酸/高尿酸血症/全血铁/开滦研究人群
Key words
Serum uric acid/Hyperuricemia/Whole blood iron/Kailuan study population
维普
万方数据