Objective To summarize the experience of surgical treatment of 73 cases of primary cardiac tumors and im-prove the level of diagnosis and treatment of cardiac tumors.Methods A retrospective analysis was performed on 73 pa-tients with cardiac tumors who were treated by cardiac macrovascular surgery in the First Affiliated Hospital of Soochow University from January 2018 to November 2022.General clinical data was collected,and their preoperative clinical man-ifestations,intraoperative surgical approach selection,tumor location and proportion,postoperative tumor pathology and prognosis were analyzed.Results A total of 30 patients showed congestive heart failure,accounting for 41.1%.There were 18 cases with embolism history,accounting for 24.7%.Two cases showed fever or systemic symptoms,accounting for 0.03%.Eight cases were complicated with arrhythmia(11.0%).Fifteen cases showed no clinical symptoms,ac-counting for 20.5%.In this group,there were 63 myxoma(86.3%),8 non-myxomatous benign tumors(11.0%),and 2 malignant tumors(2.7%),most of which originated from the left atrium,53 were located in the left atrium,4 in the right atrium,4 in the left ventricle,1 in the right ventricular outflow tract,2 in the left and right atrium,1 in the left atrium and 1 in the left atrium,and 4 involved the mitral valve.Tricuspid valve was involved in 1 case,pulmonary vein in 1 case,inferior vena cava in 1 case,pericardial cavity in 1 case.In the whole group,1 case died perioperatively,and the remaining patients had no surgery-related death.Follow-up ranged from 6 months to 5 years,with an average follow-up of 34 months,and 1 case was lost to follow-up.There was no recurrence of primary cardiac benign tumor,and 2 pa-tients with malignant tumor died at 3 months and 6 months,respectively.Conclusion Primary cardiac tumors lack char-acteristic clinical manifestations.Myxoma is the most common primary cardiac tumor,and surgical resection is an effec-tive treatment.