Objective Corneal confocal laser microscopy was applied to analyze changes in corneal nerve fibers in ado-lescent patients with primary dry syndrome and to discuss their correlation with dry eye.Methods Seventy-eight left eyes of adolescent patients with primary dry eye syndrome admitted to Ningbo Eye Hospital between January 2020 and May 2022 were selected as the observation group,and then 78 left eyes of healthy people with physical examination during the same period were selected as the control group,and the enrolled patients were examined for ocular surface disease in-dex(OSDI)values,tear film break-up test,tear secretion test and other indices(all were consistent),and other causes of dry eye were excluded,and the in vivo confocal fibre-optic microscopy related indices and OSDI scores were compared between the two groups.Pearson's test was used to analyse the correlation between corneal nerve fibre changes and dry eye in patients with primary dry syndrome.Results The diameter of the nerve fibres in the observation group was(2.12±0.58)μm,which was smaller than that in the control group[(3.21±0.45)μm].The number of nerve fibre bundles,Langerhans cell density and OSDI scores of the observation group were(7.25±2.15)/100 μm,(636.05± 38.15)/100 μm and(45.23±5.21)points,respectively,which were higher than that in the control group[(2.85± 1.36)/100 μm,(13.85±4.02)/100 μm,(11.23±3.21)points,P＜0.05].Pearson correlation test showed a nega-tive correlation between OSDI score and nerve fibre diameter in patients with primary dry syndrome(r=-0.432,P＜0.05);and a positive correlation with nerve fibre count and Langerhans cell density(r=0.562,0.515,P＜0.05).Conclusion There is a correlation between dry eye and nerve fibre diameter,number of nerve fibre bundles and Langer-hans cell density in juvenile patients with primary dry syndrome,and the above indicators can be used as suggestive fac-tors for clinical diagnosis and treatment of primary dry syndrome.
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