Objective To investigate the expression and clinical value of serum LncRNA NT-AS1 and interleukin(IL)17A in children with refractory mycoplasma pneumoniae pneumonia(RMPP).Methods A total of 148 children with MPP(MPP group)diagnosed and treated at Zhangjiakou Maternal and Child Health Hospital from February 2021 to March 2022 were selected and divided into RMPP group(48 cases)and non-RMPP group(100 cases)according to whether RMPP occurred.Sixty children who underwent surgery for hydrocele in the same period were selected as the con-trol group.The differences of serum LncRNA NNT-AS1 and IL-17A between all groups were compared.The correlation between serum LncRNA NNT-AS1,IL-17A and inflammatory markers was analyzed by Pearson correlation analysis.Mul-tivariate logistic regression analysis of factors affecting the incidence of RMPP.The predictive value of LncRNA NNT-AS1 and IL-17A in the incidence of RMPP was analyzed by subject operating characteristic curve.Results Serum LncRNA NNT-AS1 and IL-17A in the MPP group were higher than those in the control group(P＜0.05).Serum LncRNA NNT-AS1 and IL-17A in the MPP group were positively correlated with CRP,PCT,IL-6 and TNF-α(r=0.623-0.721,P＜0.001).Elevated levels of serum LncRNA NNT-AS1 and IL-17A were independent risk factors for RMPP.The area un-der the curve of RMPP in MPP children was 0.906,which was better than that of single detection.Conclusion The el-evated levels of serum LncRNA NNT-AS1 and IL-17A in children with RMPP are independent risk factors for the devel-opment of RMPP,and the combined detection of LncRNA NNT-AS1 and IL-17A is helpful in assessing the occurrence of RMPP.
Refractory mycoplasma pneumoniae pneumoniaLong chain non coding RNA NNT-AS1Interleukin 17APredictive value
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