Objective To investigate the association between sodium and potassium intake,as assessed by 24-hour urinary sodium and potassium excretion,and mild cognitive impairment(MCI)in a community population.Methods A cross-sectional study was conducted in Emin County from March to June 2019 using multi-level stratified random sampling,a to-tal of 561 community residents aged ≥ 35 years were included in this study.The mini-mental state examination(MMSE)was used to assess cognitive function.The subjects were divided into three groups according to 24-hour urinary potassium interquartile grouping:the lowest group(T1,n=187),the middle group(T2,n=187)and the highest group(T3,n=187).Multivariate linear regression model analysis and logistic regression model were used to analyze the risk of MCI.Re-sults Twenty-four-hour urinary potassium total MMSE score was lower in the T1 group than in the T3 group[25.0(20.0,28.0)vs.27.0(24.0,29.0),P=0.009],and the prevalence of MCI was significantly lower in the T3 group than in the T1 group(9.1％vs.24.6％,P＜0.001).Multivariate linear regression analysis showed that 24-hour urinary potassium was positively correlated with MMSE(β=0.027,95％CI:0.000 to 0.054,P=0.047)and 24-hour urinary sodium was nega-tively correlated with MMSE(β=-0.007,95％CI:-0.013 to-0.001,P=0.025).Multivariate logistic regression analy-sis showed that T1 and T2 groups with lower 24-hour urinary potassium increased the risk of MCI compared with T3 group with higher urinary potassium excretion by 3.222 times(95％CI:1.577 to 6.562,P=0.001)and 3.022 times(95％CI:1.513 to 6.029,P=0.002),respectively.The risk of MCI in the T2 group with higher 24-hour urinary sodium was 2.812 times(95％CI:1.502 to 5.256,P=O.001)compared with the T1 group with lower urinary sodium.Conclusion Higher sodium intake and lower potassium intake were independently associated with MCI.
24-hour urinary sodium24-hour urinary potassiumMild cognitive impairmentSimple cognitive function assessment form
维普
万方数据
