Objective To explore the application effect of case-based learning(CBL)combined with problem-based learning(PBL)in Tumor Bioinformatics teaching and students'evaluation of the teaching mode.Methods A total of 62 four-year biomedical engineering students who were studying Tumor Bioinformatics in Air Force Medical University were selected.The random digital table method was used to divide the subjects into experimental group and control group,with 31 students in each group.The experimental group adopted CBL combined with PBL teaching mode,while the con-trol group adopted traditional teaching mode.After the teaching,the teaching effect was evaluated by the test of proposi-tion.The questionnaire survey was used to evaluate the students'satisfaction with the two teaching modes.Results By statistical analysis,the experimental group students'scores on multiple-choice questions(24.52±2.69),short-answer questions(35.21±3.03),essay questions(24.28±3.41)and total scores(78.15±5.89)were higher than those of the control group(21.94±3.17,32.85±2.78,22.31±3.89,73.81±6.21,P＜0.05).In the questionnaire survey,the ex-perimental group had better approval of improving the enthusiasm for theoretical knowledge learning,fostering clinical transformational thinking,improving the mastery of theoretical knowledge,expanding the knowledge of oncology medi-cine,improving the ability to solve clinical problems,improving the ability of independent learning,improving the effi-ciency of literature retrieval,and improving the ability of cooperative learning than the control group(P＜0.05).Conclu-sion CBL combined with PBL has achieved better results in the teaching of Tumor Bioinformatics courses,which im-proves the students'learning ability and knowledge mastery,and the students are highly satisfied with this teaching mode.
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