Venetoclax combined with azacitidine in treatment of acute megakaryoblastic leukemia transformed from primary myelofibrosis:report of 1 case and review of literature
We retrospectively analyzed the clinical data of an elderly patient of acute megakaryoblastic leukemia trans-formed from primary myelofibrosis treated with venetoclax combined with azacitidine in Gansu Provincial People's Hospi-tal and reviewed the relevant literature.This patient,a 72-year-old man,was diagnosed with primary myelofibrosis and was transformed to acute megakaryoblastic leukemia after 2 years of treatment with ruxolitinib,then given venetoclax com-bined with azacitidine.After the first course of treatment,the patient had partial remission of bone marrow and clinical improvement significantly.After the second course of treatment,although the bone marrow had complete remission and flow minimal residual disease(MRD)was negative,agranulocytosis persisted for up to 45 days and finally died due to in-fection.
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