Objective To evaluate the evaluation effect and clinical application value of CT angiography(CTA)on plaque status and lumen stenosis in patients with coronary heart disease,in order to provide reference for clinical search for appropriate non-invasive examination methods.Methods The clinical data of 166 patients with coronary heart dis-ease admitted to the Seventh People's Hospital of Zhengzhou from October 2019 to October 2022 were retrospectively ana-lyzed.Coronary angiography(CAG)was used as the"gold standard"to calculate the consistency of CTA and CAG re-sults.The types of coronary segmental plaque in patients with different degrees of stenosis were compared based on CTA,and the effects of coronary plaque characteristics and stenosis degree on the risk of major adverse cardiac events(MACE)were analyzed.Results A total of 172 coronary stenosis lesions were detected by CAG,and the sensitivity,specificity and coincidence rate of CTA were 96.51%(166/172),71.54%(352/492)and 78.01%(518/664),respectively,which were in good agreement with the results of CAG(Kappa=0.818,P<0.001).A total of 89 coronary plaques were detected by CTA.The proportions of non-calcified plaques(35.71%,10/28)and mixed plaques(32.14%,9/28)in the mild stenosis segments were lower than those in the moderate/severe stenosis segments[57.37%(35/61),39.34%(24/61)].The proportion of calcified plaques in mild stenosis segments(32.14%,9/28)was higher than that in mod-erate/severe stenosis segments(3.27%,2/61),and the difference was statistically significant(P<0.05).Non-calci-fied plaque volume,plaque length and lumen diameter stenosis rate were independent risk factors for MACE(P<0.001).Conclusion CTA can accurately evaluate the plaque status and lumen stenosis in patients with coronary heart disease.