首页|七叶皂苷钠片联合泼尼松治疗特发性面神经麻痹临床效果观察

七叶皂苷钠片联合泼尼松治疗特发性面神经麻痹临床效果观察

Clinical effect observation of prednisone combined with sodium aescinate tablets in the treatment of facial neuritis

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目的 观察七叶皂苷钠片联合泼尼松治疗急性特发性面神经麻痹患者的效果,探讨该方案治疗特发性面神经麻痹的临床价值.方法 选取2020年1月-2022年12月就诊于蚌埠医科大学第一附属医院神经内科的特发性面神经麻痹患者60例作为研究对象,应用随机数字表法将患者分为观察组和对照组,每组30例.对照组采用常规治疗,观察组在常规治疗的基础上加用七叶皂苷钠片.治疗30 d后,比较2组患者治疗后面神经功能评分、House-Brackman(H-B)分级并记录用药期间不良事件发生情况.结果 观察组患者临床治疗后基本痊愈9例(30.0%),显效10例(33.3%),有效9例(30.0%),无效2例(6.7%),对照组患者临床治疗后基本痊愈7例(23.3%),显效9例(30.0%),有效6例(20.0%),无效8例(26.7%),2组治疗总有效率比较差异有统计学意义(P<0.05);观察组患者治疗后面神经功能评分为(69.33±14.41)分,高于对照组[(61.63±9.45)分],2组比较差异有统计学意义(P<0.05);2组患者治疗后H-B分级比较差异无统计学意义(P>0.05);2组患者在临床治疗过程中不良事件发生率比较差异无统计学意义(P>0.05).结论 七叶皂苷钠片联合泼尼松可以促进特发性面神经麻痹功能改善,且具有较好的安全性.
Objective To explore the clinical efficacy of combining sodium aescinate tablets with prednisone in the treat-ment of facial neuritis and to explore the clinical value of this scheme in treating facial neuritis.Methods This study en-rolled 60 patients with facial neuropathy from January 2020 to December 2022 at the Department of Neurology,the First Affiliated Hospital of Bengbu Medical University.The patients were randomly divided into two groups using a random number table method:the control group(n=30)received conventional treatment,while the observation group(n=30)received conventional therapy along with the addition of sodium aescinate tablets.After a 30-day treatment period,the clinical effects were assessed by comparing neural function scores,House-Brackman(H-B)rating,and record adverse e-vents between the two groups.Results Following clinical treatment,the observation group showed 9 patients achieving complete recovery(30.0%),10 patients with significant improvement(33.3%),9 were effective(30.0%),and 2 pa-tients with no improvement(6.7%).In the control group,7 patients achieved complete recovery(23.3%),9 patients showed significant improvement(30.0%),6 patients had moderate improvement(20.0%),and 8 patients showed no improvement(26.7%).The difference in total effective rate between the two groups was statistically significant(P<0.05).The mean score of the patients in the observation group was 69.33±14.41,which was higher than that in the control group(61.63±9.45)after treatment,with a statistical difference(P<0.05).There was no significant difference in H-B grade between the observation group and the control group(P>0.05).Additionally,no significant difference in adverse events was observed between the observation group and the control group(P>0.05).Conclusion The combi-nation of sodium aescinate tablets and propionate promotes improved facial neuropathic function and enhances safety.

Facial neuritisPrednisoneSodium aescinate tablets

骆嵩、王晓蕊、马博、屈洪党

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蚌埠医科大学第一附属医院神经内科,安徽蚌埠 233004

特发性面神经麻痹 泼尼松 七叶皂苷钠片

安徽省临床医学研究转化专项安徽省教育厅重点项目安徽省"江淮名医"培育工程项目(2022)

2023042951070200762022AH051480

2024

中华全科医学
中华预防医学会,安徽省全科医学会

中华全科医学

CSTPCD
影响因子:1.688
ISSN:1674-4152
年,卷(期):2024.22(4)
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