Objective To investigate the therapeutic effect of transcranial direct current stimulation(tDCS)on patients with depression,and to observe its influence on the patients'cognitive function in order to provide a reference for the clinical application of tDCS in the treatment of depression.Methods A total of 112 patients with depression admitted to the Second People's Hospital of Lishui from March to December 2023 were selected as observation objects,and divided into control group(n=55)and tDCS group(n=57)according to whether they were treated with tDCS or not.The 17-item Hamilton depression scale(HAMD-17)score,Wisconsin card sorting test(WCST)score,and adverse reactions were compared between the two groups.Results After treatment,the overall efficacy rate of the tDCS group was higher than that of the control group[89.47％(51/57)vs.69.09％(38/55),P＜0.01].Before treatment,there was no sig-nificant difference in HAMD-17 score and WCST score between the two groups(P＞0.05).After treatment,the HAMD-17 scores of both groups were significantly decreased(P＜0.05).After 4 weeks of treatment,the HAMD-17 score of the tDCS group was lower than that of the control group[(10.64±2.57)points vs.(15.82±2.96)points].After 4 weeks of treatment,the 5-item WCST scores of the tDCS group were better than those of the control group(P＜0.001),and the patients'cognitive function was significantly improved.During treatment,adverse events occurred in both groups,inclu-ding 1 case of nausea in the control group,1 case of skin tingling,and 1 case of nausea in the tDCS group.There was no statistically significant difference in side effects between the two groups(P＞0.05).Conclusion tDCS can effectively relieve the clinical symptoms of depression patients,the effect is obvious,and can improve the cognitive function of de-pression patients.
关键词
经颅直流电刺激/抑郁症/认知功能/治疗效果
Key words
Transcranial direct current stimulation/Depression/Cognitive function/Therapeutic effect
维普
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