Objective To explore the clinical effect of Weifuchun tablets combined with omeprazole enteric-coated cap-sules on patients with functional dyspepsia and their influence on serum pepsinogen and gastrin-17 levels.Methods Using a random number table,128 patients diagnosed with functional dyspepsia at Yuyao Hospital of Traditional Chinese Medicine between October 2021 and December 2022 were divided into two groups:Weifuchun group and Mosapride group,eaching consisting of 64 cases.The mosapride group was given a combination of omeprazole and Mosapride tab-lets,while the Weifuchun group was given a combination of omeprazole and Weifuchun tablets.After 4 weeks of continu-ous treatment,the therapeutic effect,serum pepsinogen,and gastrin-17 levels were compared between the two groups.Results After 4 weeks of treatment,the Weifuchun group demonstrated a higher total effective rate(87.50％,56/64)compared to the Mosapride group(71.88％,46/64),with a statistically significant difference(x2=4.827,P＜0.05).The Weifuchun group also exhibited higher levels of pepsinogen Ⅰ[(113.20±10.21)pg/L]compared to the Moxa-pride group[(98.26±9.64)µg/L,P＜0.05].Moreover,the Weifuchun group showed lower levels of pepsinogen Ⅱ[(17.21±2.58)μg/L]and gastrin-17[(15.31±2.09)pmol/L]compared to the Mosapride group[(20.31±3.11)pg/L,(18.22±2.67)pmol/L,P＜0.05].Conclusion The combination of Weifuchun tablets and omeprazole enteric-coated capsules significantly improves the clinical symptoms of patients with functional dyspepsia.It effectively corrects abnormal levels of serum pepsinogen and gastrin-17,leading to improved prognosis and enhanced quality of life for pa-tients.
维普
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