Observation on the therapeutic effect of combined butylphthalide and repeated transcranial magnetic stimulation on mild cognitive impairment after cerebral infarction
Observation on the therapeutic effect of combined butylphthalide and repeated transcranial magnetic stimulation on mild cognitive impairment after cerebral infarction
Objective This study aims to explore the efficacy and safety of combing butylphthalide with repetitive tran-scranial magnetic stimulation for treating mild cognitive impairment in patients following cerebral infarction,offering valu-able insights for clinical treatment.Methods A total of 190 patients with mild cognitive impairment after cerebral infarc-tion were randomly divided into either Group A(n=95)or Group B(n=95)at Longyou People's Hospital from Febru-ary 2020 to January 2023.Group A received butylphthalide treatment,while Group B received a combination of bu-tylphthalide and repetitive transcranial magnetic stimulation.The study aimed to compare the treatment effects,cognitive function,cerebral blood flow indicators,inflammatory reactions indicators,and adverse reactions between the two groups.Results The total effective rate of treatment in Group B(90.53％,86/95)was significantly higher than in Group A(71.58％,68/95,P＜0.05).Both groups demonstrated improved cognitive function compared to before treatment,with Group B showing a significantly higher Montreal cognitive assessment(MoCA)score than Group A[(26.33±2.50)points vs.(24.21±2.84)points,P＜0.05];After treatment,both groups exhibited decreased pulsatile index of blood flow in both groups of patients decreased,and the systolic and average blood flow velocities of blood flow and increased systolic and average blood flow velocities(P＜0.05).However,Group B showed better cerebral blood flow indicators compared to Group A(P＜0.05).Post-treatment C-reactive protein,tumor necrosis factor-α,and interleukin-1β de-creased in both groups(P＜0.05),with all indicators in Group B being lower than in Group A(P＜0.05).There were no significant differences in adverse reactions between the two groups(P＞0.05).Conclusion The combination of bu-tylphthalide and repetitive transcranial magnetic stimulation demonstrates a significant therapeutic effect on mild cognitive impairment following cerebral infarction.It effectively improves cognitive function,enhances cerebral blood flow indica-tors,reduces inflammatory reactions,and exhibits minimal adverse reactions.This treatment approach is both effective and safe,warranting its promotion.
关键词
丁苯酞/重复经颅磁刺激/脑梗死/认知障碍/脑血流/炎症反应指标
Key words
Butylphthalide/Repetitive transcranial magnetic stimulation/Cerebral infarction/Cognitive impairment/Cerebral blood flow/Inflammatory response indicators
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