Corona virus disease 2019(COVID-19)is an acute infectious disease caused by severe acute respiratory syn-drome coronavirus 2 with high incidence,strong infectivity and rapid state change.The characteristics of type 2 diabetes mellitus(T2DM)with COVID-19 are uncontrollable,many complications,high critical rate and mortality.Blood glucose variability is one of the main reasons.Currently,there is no accepted time in range(TIR),and TIR is closely associated with prognosis.Glucose variability parameters are independent risk factors for predicting mortality in critical patients.The monitoring of glucose variability is important to realize the fine management of blood glucose.This article reviews the re-search progress of the effect of glycemic control on the prognosis of T2DM with COVID-19.The main contents include the epidemiological status,major pathophysiological mechanisms(e.g.,cytokine release syndrome,abnormal expression of angiotensin-converting enzyme 2,etc.),glycemic control goals,and scientific management of patients.This review pro-vides a theoretical reference for optimizing the diagnosis and treatment strategy,improving the prognosis,and reducing the incidence of complications and mortality.
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