Ovarian senescence is characterized by a decline in the number and quality of oocytes or follicular pools,cau-sing a decline in fertility.With the continuous development of social and economic levels and the promulgation of China's three-child policy,there is a growing tension between the ever-delayed reproductive age and the ever-declining follicular pool.Declining fertility at an advanced age is also a serious challenge.How to delay ovarian senescence and meet the reproductive needs of women of childbearing age has become a focus of medical researchers in recent years.At present,common adipocytokines are biologically active molecules mainly produced by adipocytes.They are involved in a variety of physiological processes such as energy metabolism and internal and external environment balance of the body and may be involved in the occurrence of a series of obesity-related diseases such as diabetes and atherosclerosis.In the female reproductive system,some common adipocytokines,such as leptin,visfatin,adiponectin,chemokine,and adi-poinflammatory factors,regulate follicle quality and growth and development through endocrine,paracrine,and autocrine pathways.Leptin has been found to promote follicle maturation within a certain range of concentrations,and either too high or too low concentrations may cause adverse effects on oocytes.Visfatin has been reported to stimulate ovarian angio-genesis,thereby enhancing fertility.Adiponectin can regulate the metabolism and apoptosis of granulosa cells and cumu-lus cells through related pathways,thereby protecting follicle development.Chemerin inhibits granulosa cell proliferation,induces apoptosis,and inhibits follicle-stimulating hormone-induced production of estradiol and progesterone by granulosa cells.Inflammation caused by adipocytokines may be one of the mechanisms involved in the age-related regulation of folli-cle number.Through reviewing relevant literature,this paper attempts to explore the role of common adipocytokines in o-varian aging,to provide some theoretical references for general practitioners in the health care of women of reproductive age.
维普
万方数据
