Objective There are many nursing difficulties in diabetic foot,and the disability rate is high.This study in-vestigated the effect of"one point,two sources"adaptive nursing strategy on self-efficacy,treatment compliance and blood glucose level in diabetic foot patients.Methods A total of 84 patients with diabetic foot who were admitted to the Endocrine Clinic of Shaoxing People's Hospital from March 2020 to March 2022 were selected and divided into control group(42 cases)and observation group(42 cases)by drawing lots.The control group was given routine care,and the observation group was given"one point,two sources"adaptive nusing on the basis of routine care for 3 months.Self-effi-cacy,treatment compliance and blood glucose levels were compared between the two groups.Results The score and to-tal score of self-efficacy(diabetes self-efficacy scale,DSES,diet,medication,exercise,disease monitoring,foot care and emergency management)were higher than before care(P<0.05),and the scores of the observation group were high-er than that of the control group(P<0.05).Post-care treatment compliance in the observation group was higher than that of the control group(P<0.05).Fasting blood glucose(FPG),2 h postprandial blood glucose(2hPG)and glycosylated hemoglobin(HbA1c)were decreased compared with before care[(6.44±1.32)mmol/L,(9.24±2.10)mmol/L and(5.80±0.57)%vs.(7.13±1.45)mmol/L,(11.02±3.23)mmol/L and(6.19±0.56)%,P<0.05].Conclusion The implementation of"one point,two sources"adaptive nursing strategy for diabetic foot patients can ef-fectively improve the level of self-efficacy and treatment compliance,and reduce the level of blood glucose,the effect is i-deal.