Objective To analyze the factors associated with osteonecrosis(ON)in patients with systemic lupus erythe-matosus(SLE)in order to reduce the impact on patients'quality of life.Methods A total of 65 SLE patients with ON(ON group)and 65 SLE patients without ON(non-ON group)who hospitalized in the Department of Rheumatology and Immunology of Shanxi Bethune Hospital from January 2013 to December 2022 were selected.The clinical symptoms,la-boratory examination and treatment were compared between the two groups.Logistic regression was used to analyze the risk factors for SLE complicated with ON.Results Among the case groups,53 cases(81.5％)were bilateral ON;There were 29 cases(44.6％)of bone pain and 18 cases(27.6％)of complex multiple symptoms.In univariate analy-sis,there were statistically significant differences in disease course,hormone accumulation time,menopausal history,nervous system involvement and myalgia muscle weakness,and there were statistically significant differences in white blood cell count,percentage of total T cells and suppressor T(Ts)cells,percentage and absolute value of natural killer T(NKT)cells,standardized dilute Russell's viper venom time(dRVVT)ratio,activated partial thromboplastin time,and history of aspirin,statins,bisphosphonates,hydroxychloroquine and immunosuppressants in medication use(P＜0.05).Multivariate logistic regression analysis showed that the percentage of total T cells and the ratio of standard-ized dRVVT were the influencing factors of SLE with ON.Conclusion Appropriate use of immunosuppressants,atten-tion to balancing medication interactions in SLE treatment,and special attention to patients with nervous system involve-ment and muscle pain and weakness.Ts cells in the lymphocyte subpopulation play an important regulatory role in ON.Individuals with higher standardized dRVVT ratios are more likely to have ON or may predict the occurrence of ON.Therefore,caution should be used in clinical diagnosis and treatment.
维普
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