Objective To analyze the clinical characteristics of patients with out-of-hospital cardiac arrest(OHCA)and identify the factors affecting the success of cardiopulmonary resuscitation(CPR).Additionally,explore the current treat-ment problems and propose rational and effective improvement strategies.Methods A total of 229 patients with OHCA and concurrent CPR,who received emergency treatment at the First People's Hospital of Lin'an District,Hangzhou City from January 1,2019 to December 31,2022,were selected as the research subjects.According to the resuscitation out-comes,they were categorized into a successful resuscitation group(71 cases)and a failed resuscitation group(158 ca-ses).The Utstein model was used to retrospectively analyze the relevant factors affecting the success of OHCA patient re-suscitation.By comparing it with current domestic research data,we aim to identify the existing problems in treatment and propose reasonable and effective solutions.Results Univariate analysis showed that several risk factors affecting the success rate of return of spontaneous circulation(ROSC)in OHCA patients.These factors included the pre-hospital e-mergency response time,presence or absence of witnesses,immediate CPR,presence or absence of CPR within 6 mi-nutes,presence or absence of pre-hospital emergency,type of first monitored heart rhythm,frequency of defibrillation,duration of defibrillation,and total duration of CPR(P<0.05).Multivariate logistic regression analysis showed that both pre-hospital emergency response time(P=0.020)and the presence or absence of CPR within 6 minutes(P=0.002)were independent risk factors for successful resuscitation in OHCA patients.Specifically,an increase in pre-hospital emergency response time was associated with a decrease in the success rate of resuscitation by approximately 27.3%per unit increase(95%CI:0.557-0.950).Individuals who received CPR within 6 minutes had a significantly higher suc-cess rate compared to those without timely intervention,approximately 8.8 times higher odds for successful resuscitation were observed among this group(95%CI:2.226-34.804).Conclusion Shortening the response time of pre-hospital first aid and performing high-quality CPR as soon as possible after the occurrence of cardiac arrest can effectively improve the success rate of ROSC in out-of-hospital cardiac arrest patients.