Objective To explore the value of SPECT-CT imaging with 99Tcm-MIBI nanoparticle in evaluating the drug resistance of breast cancer to neoadjuvant chemotherapy,to find a non-invasive evaluation method to predict the efficacy of neoadjuvant chemotherapy.Methods The imaging agent 99Tcm-MIBI nanoparticle was prepared and the nude mouse model of carcinoma of breast was established.The nude mouse model was treated with combination chemotherapy of epi-rubicin and docetaxel(ET)as follows:on the 1st day,epirubicin 40 mg/(m·d)was administered via tail vein for two days,then on the 3rd day,docetaxel 60 mg/m2 was administered via tail vein,3 weeks per cycle,with a total of 3 cycles of chemotherapy.99Tcm-MIBI nanoparticles SPECT-CT imaging was used before and after chemotherapy to observe the image changes.The ratio of tumor to surrounding background(T/B)of each nude mouse model of breast cancer was cal-culated by ROI technology.Results According to UICC solid tumor efficacy evaluation criteria,the efficacy of combined chemotherapy in nude mice with human breast cancer was evaluated,In 40 nude mouse models of human breast cancer,27 partial remission(PR),12 disease stability(SD),and 1 disease progression(PD);The T/B of 99Tcm-MIBI nanop-articles SPECT-CT imaging before chemotherapy in nude mouse model of human breast cancer was 2.98±0.73,The T/B value of 99Tcm-MIBI nanoparticle SPECT-CT imaging after chemotherapy in the partially relieved(PR)nude mouse mod-el was 1.52±0.59,and there was a significant difference in T/B value compared to before chemotherapy(P＜0.05);The T/B of 99Tcm-MIBI nanoparticle SPECT-CT imaging in the disease stable(SD)nude mouse model after chemothera-py was 3.12±1.09,and the difference was not significant compared to before chemotherapy(P＞0.05).Conclusion For breast cancer patients,99Tcm-MIBI nanoparticles SPECT-CT imaging is expected to evaluate the therapeutic effect of neoadjuvant chemotherapy drugs,which is a non-invasive method to evaluate the drug resistance of breast cancer to neo-adjuvant chemotherapy.
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