Evaluate the abnormal white matter blood perfusion by 3D-ASL technique and its correlation with cognitive function in patients with cerebral infarction
Evaluate the abnormal white matter blood perfusion by 3D-ASL technique and its correlation with cognitive function in patients with cerebral infarction
Objective Three-dimensional arterial spin labeling(3D-ASL)is used to assess the white matter blood perfu-sion status of cerebral infarction patients,the Montreal cognitive assessment(MoCA)is used to assess the cognitive func-tion of patients,and the relationship between white matter blood perfusion status and cognitive function is analyzed.Methods Clinical data of 123 patients with cerebral infarction admitted to Anyang Regional Hospital in Puyang City from March 2020 to March 2023 were collected,and cerebral blood flow(CBF)in each white matter region was detected by MRI 3D-ASL.Patients were divided into control group(74 cases)and cognitive dysfunction(CD)group(49 cases)according to whether CD occurred 3 months after discharge.Logistic regression analysis model was used to determine the factors affecting the occurrence of cerebral infarction CD.Pearson correlation was used to analyze the correlation between white matter CBF and MoCA score in patients with cerebral infarction.Receiver operating characteristic curve(ROC)was used to analyze the predictive effect of CBF in white matter region on CD occurrence in patients with cerebral infarc-tion.Results Among the 123 patients,the incidence of CD was 39.84％(49/123),and the MoCA score of CD group was lower than that of control group(P＜0.05).Logistic regression analysis showed that high level of Hcy and low level of CBF in frontal,parietal and occipital white matter areas were independent risk factors for the occurrence of cerebral in-farction CD(P＜0.05).Pearson correlation analysis showed that CBF values in frontal,parietal and occipital lobes were positively correlated with MoCA scores(P＜0.05).ROC analysis results showed that the CBF value of frontal,parietal and occipital lobes and the AUC of the CBF value combined with the CBF value of the three lobes were 0.542,0.634,0.633 and 0.793,respectively,and the predictive efficiency of the CBF value combined with the CBF value of the three lobes was higher than that of the single detection(P＜0.05).Conclusion There is abnormal white matter blood perfu-sion in patients with cerebral infarction CD.The CBF values of frontal,parietal and occipital lobes are positively correla-ted with MoCA scores.The combination of the three has high predictive value for the occurrence of CD after cerebral in-farction.
维普
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