Pyroptosis is a newly discovered form of programmed cell death that relies on caspase-1 and inflammasome ac-tivation to initiate the cell death process.This pathway is characterized by compromised membrane integrity and the re-lease of numerous pro-inflammatory factors.Gasdermin E(GSDME),a member of the gasdermin family,plays a pivotal role in pyroptosis induction.It is widely expressed in normal tissues and can convert apoptosis into pyroptosis.Kidney diseases pose significant health risks to humans.In recent years,researchers have gradually revealed and confirmed the involvement of GSDME-dependent pyroptosis in the pathogenesis of kidney diseases.A comprehensive understanding of the role of GSDME-dependent pyroptosis in renal disease will facilitate the identification of novel targets for diagnosing and treatment.To provide valuable references for clinical and basic researchers,we present a review and summary of studies investigating the association between GSDME-dependent pyroptosis and renal diseases,including acute kidney in-juries,diabetic nephropathy,renal carcinoma,obstructive nephropathy,and lupus glomerulonephritis.
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