Intrauterine adhesion(IUA),also known as Asherman's syndrome,is a common reproductive system disorder in women of reproductive age,often occurring as a result of postpartum infection,uterine surgery,or genital tuberculosis.IUA is a fibrotic disease caused by tissue damage.When the trauma to the endometrial basement membrane leads to re-pair disorder,excessive deposition and reorganization of extracellular matrix and proliferation of fibrous connective tissue replace the normal endometrium.This can ultimately cause partial or complete obstruction of uterine cavity or cervical ca-nal,which may lead to various complications,including cyclical pelvic pain,menstrual disturbance,and disminished fer-tility,seriously affecting the physical and mental health of women.Transcervical resection of adhesion is the current method for IUA treatment,but the high recurrence rate of postoperative adhesion and subsequent infertility make the treat-ment of IUA still a significant challenge.Non-coding RNAs(ncRNAs),a class of RNA molecules that lack protein-cod-ing capacity,are integral to the regulation of gene expression and are significant contributors to the metabolic life activity of organisms and the development of diseases.Recent studies have identified associations between TGF-β1/Smad,Wnt/β-catenin,and NF-κB signaling pathways and the development of IUA.ncRNAs potentially modulate endometrial fibro-genesis by targeting key components within these pathways.ncRNAs mainly include microRNA(miRNA),long non-cod-ing RNA(IncRNA),and circular RNA(circRNA),which are expected to be therapeutic targets and diagnostic markers for IUA.This review summarizes the progress of research on ncRNAs and IUA,to offer novel insights for the prevention and treatment of IUA,ultimately enhancing patients'quality of life.
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