Objective To explore the efficacy and safety of acupuncture combined with Zusanli acupoint injection of me-toclopramide in the treatment of persistent hiccups,and to compare the differences in the therapeutic effects of this meth-od on central and peripheral persistent hiccups.Methods A total of 48 patients with persistent hiccups were selected from the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)from July 2018 to August 2022,including 36 patients in the central treatment group and 12 patients in the peripheral treatment group.The two groups were treated with acupuncture at Cuanzhu,Danzhong,Zhongwan,Geshu,Neiguan,Zusanli and other points,and the needles were retained for 30 min.After taking the needle,1ml metoclopramide hydrochloride was injected into the right Zusanli(ST36),and the same dose was injected into the left Zusanli 4-6 hours later,for a total of 3 treatments.Hiccups assessment instrument(HAI)was used to assess the severity of hiccups in the two groups after each treatment and after the end of the treatment.The total effective rate of the two groups was compared after treatment.The total effective rate of the two groups was compared after treatment.Results After treatment,there were statistically significant differences in HAI scores between before treatment and after the first,second and third treatment,between af-ter the first treatment and after the second and third treatment,and between after the second and third treatment in two groups(all P＜0.05).After the first,second and third treatment,the HAI scores of the peripheral treatment group were significantly lower than that of the central treatment group(4.25±2.60 vs.6.69±2.07,1.96±1.75 vs.3.64±3.08,0.45±0.36 vs.2.18±2.06,P＜0.05).The total effective rate of the peripheral treatment group was significantly higher than that of the central treatment group(91.67％vs.52.78％,x2=4.267,P=0.039).Conclusion The method of acupuncture combined with Zusanli acupoint injection is effective for persistent hiccups caused by both central and periph-eral causes,and the therapeutic effect is better for peripheral causes.
维普
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