Acquired hemophilia following haploidentical hematopoietic stem cell transplantation for acute lymphoblastic leukemia in children:one case report and literature review
Acquired hemophilia following haploidentical hematopoietic stem cell transplantation for acute lymphoblastic leukemia in children:one case report and literature review
Acquired hemophilia(AH)is a rare disease caused by autoantibodies against factors.We reported a case of acute lymphoblastic leukemia(T-lineage,high-risk)in a child who developed acquired hemophilia after haploidentical hematopoietic stem cell transplantation(paternal donor,HLA 5/10)and reviewed the relevant literature.Laboratory tests showed decreased coagulation factor Ⅸ activity(FⅨ∶C),FⅪ∶C,and FⅫ∶C,and an elevated FⅨ inhibitor ti-ter,which is rare the clinic.After diagnosis,the child was treated with methylprednisolone in combination with cyclospo-rine A.With improvement of symptoms,the patient was discharged and continued to take cyclosporine A and methylpred-nisolone regularly.Four months after discharge,symptoms recurred,and the treatment regimen was changed to double-dose methylprednisolone combined with cyclosporine A immunosuppressive therapy,and the child was discharged with improvement.There was no recurrence of symptoms until March 2023.
关键词
获得性血友病/单倍体造血干细胞移植/儿童/凝血因子Ⅸ抗体
Key words
Acquired hemophilia/Haploidentical hematopoietic stem cell transplantation/Children/Autoantibodies against factor Ⅸ
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