Objective Doctor-patient communication ability is one of the important skills to improve the competency of general practitioners,and it is also an important content in the general practice standardized training.This study aims to explore the application of Calgary-Cambridge guidelines doctor-patient communication model in the teaching of general practitioners'doctor-patient communication,so as to provide reference for improving the doctor-patient communication a-bility and humanistic quality.Methods A total of 30 general practitioners who underwent general practice standardized training in the Qinghai University Affiliated Hospital from May 2021 to May 2023 were selected.They were divided into experimental group(n=15)and control group(n=15)by random number table method.The control group only received the traditional doctor-patient communication skills training during the clinical work,while the experimental group received the Calgary-Cambridge guideline doctor-patient communication skills training.The doctor-patient communication effec-tiveness evaluation scale(SEGUE)was used to evaluate the two groups of doctors before training,3 months,6 months,and 9 months after training.Results There was no significant difference in the scores of doctor-patient communication skills between the two groups before the training(P>0.05).After training,the scores of communication skills in both groups showed a significant upward trend,and there was a significant difference between the two groups.With the exten-sion of time the difference became more obvious as the scores of communication skills in 3 months[(15.67±1.84)points vs.(11.67±2.06)points],6 months[(19.53±1.73)points vs.(15.73±1.49)points,and 9 months(21.07±1.22)points vs.(18.20±1.70)points].The scores of the experimental group were significantly higher than those of the con-trol group in the aspects of preparation and initiation,information collection,information giving,understanding patients,and ending inquiry(P<0.05).Conclusion The Calgary-Cambridge guideline doctor-patient communication model is superior to the traditional doctor-patient communication model in all dimensions of doctor-patient communication evalua-tion,including preparation and initiation,information collection,information giving,understanding the patients,and ending inquiry.