Objective To analyze the changes of plantar pressure in patients with different altitudes,and to provide a quantitative basis for the changes of plantar pressure in patients with Tibetan knee osteoarthritis(KOA)living in the plat-eau.Methods Patients with knee osteoarthritis who underwent total knee arthroplasty in the Second People's Hospital of Tibet Autonomous Region from March to August 2023,were selected according to their long-term residence,and 29 ca-ses were classified according to their long-term residence,29 cases were 3 000-3 700 m,38 cases were 3 701-4 500 m,and 27 cases were 4 501-5 500 m.Static standing and dynamic walking analysis was performed using the LorAn plantar pressure test system,and the correlation between different elevation gradients and plantar pressure were analyzed by Spearman method.Results There were significant differences in T1,MH and LH between the replaced and non-re-placed sides(P<0.05).Differences in patient static indices,foot-axis angle between replacement and non-replacement sides,pelvic rotation,walking speed,and patient joint scores were statistically significant between elevations(P<0.05).The static standing and dynamic walking indexes were negatively correlated with altitude(P<0.05),joint scores were positively correlated with altitude(P<0.05),plantar pressure peaks in T1 and M4 regions and stress time ratios in M5 region were negatively correlated with altitude(r=-0.287,-0.282,-0.252,P<0.05),and BMI were positively correlated with mid-foot and post-foot pressure peaks(r=0.330,0.238,0.226,P<0.05).Conclusion The change of the peak plantar pressure can be used as an indicator to monitor the occurrence of knee joints in Tibetan people living at different altitudes.Tibetan patients with osteoarthritis of the knee who live at high altitudes have poor balance compared with patients at very high altitudes.