Objective To investigate the prognostic impact of lymph node ratio(LNR)on 2018 International Federation of Gynaecology and Obstetrics Stage ⅢC1p cervical cancer patients.Methods A total of 89 patients with lymph node-positive cervical cancer from January 2014 to December 2017 in the Oncology Department of the First Affiliated Hospital Bengbu Medical University underwent radical hysterectomy and systematic pelvic lymphadenectomy with or without ab-dominal aortic dissection.All patients received concurrent chemoradiotherapy.LNR was defined as the ratio of positive lymph nodes to the total number of LNS removed.Patients were divided into 2 groups according to LNR;LNR＜0.06(42 cases)and LNR≥0.06(47 cases).The prognostic value of LNR was assessed by univariate log-rank test and multivari-able Cox regression models.Results The median follow-up was 44.6 months(range,6-115 months),and the 5-year disease-free survival(DFS)rate for the entire cohort was 61.6％,while the 5-year overall survival(OS)rate was 69.7％.The 5-year DFS rates for LNR＜0.06 and LNR≥0.06 were 65.4％and 54.2％,respectively(P=0.027).Fur-thermore,the 5-year OS rates for LNR＜0.06 and LNR≥0.06 were 82.8％and 59.6％,respectively(P=0.003).In multivariable analysis,LNR≥0.06 was associated with worse DFS(HR=2.040,95％CI:1.130-3.870,P=0.013)and OS(HR=1.940,95％CI:1.020-3.780,P=0.038).Conclusion LNR≥0.06 may be an independent prognos-tic factor for decreased DFS and OS in patients with stage ⅢC1P cervical cancer.
维普
万方数据
