Objective To investigate the expression of programmed death receptor 1(PD-1)and programmed death re-ceptor-ligand 1(PD-L1)in the tissues of patients with platinum-resistant ovarian epithelial cancer,and to analyze the re-lationship between the expression of PD-1 and PD-L1 in patients with platinum-resistant ovarian epithelial cancer and clinical characteristics and prognosis.Methods The tissue paraffin blocks of 111 patients with ovarian cancer(71 cases of platinum-resistant tissue paraffin blocks and 40 cases of platinum-sensitive tissue paraffin blocks)who underwent surgi-cal treatment in the First Affiliated Hospital of Bengbu Medical University from January 2018 to June 2021 were collected,and 10 cases of benign ovarian tissue paraffin blocks were taken as controls.The expression levels of PD-1 and PD-L1 in ovarian cancer tissues were detected by ELiVisionTM immunohistochemistry method,and the relationships between the ex-pression levels and pathological features and prognosis were analyzed.Results The positive rates of PD-1 and PD-L1 in the platinum-sensitive group and platinum-resistant group were 22.5％,32.5％and 42.3％,53.5％,respectively.The positive rates of PD-1 and PD-L1 in the drug-resistant group were higher than those in the platinum-sensitive group(P＜0.05).The positive expression rates of PD-1 and PD-L1 in serous and non-serous cancer tissues were 50.0％,61.5％and 21.1％,31.6％,respectively.The positive expression rates of PD-1 and PD-L1 in surgical pathological stage Ⅲ-Ⅳand Ⅰ-Ⅱ were 51.0％,63.3％,and 22.7％,31.8％,respectively.The expressions of PD-1 and PD-L1 were signifi-cantly lower than those in serous carcinoma and stage Ⅲ to Ⅳ patients,with statistical significance(P＜0.05).The mul-tifactorial Cox proportional risk model shows:PD-1 positive group(HR=3.905,P=0.001),PD-L1 positive group(HR=4.581,P=0.002),surgical pathological stage Ⅲ and Ⅳ stages(HR=3.948,P=0.026)were independent risk prognostic factors affecting survival of patients with platinum-resistant ovarian epithelial cancer.Survival analysis showed that the two-year survival rate of PD-1 and PD-L1 positive patients were lower than that of negative patients(P＜0.05).Conclusion The high expression of PD-1 and PD-L1 in ovarian epithelial carcinoma tissues is related to drug resist-ance,which leads to malignant progression of tumor and shortened survival time,and is one of the indicators of poor prog-nosis of patients.
Epithelial ovarian cancerProgrammed death receptor-ligand 1Platinum resistanceChemotherapy resist-anceImmunotherapyProgrammed death receptor 1
维普
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