Objective To investigate the expression levels of long non-coding RNA para-plaque assembly transcript 1(LncRNA NEAT1)and SP1 in the serum of patients with Parkinson's disease(PD)and their relationship with disease severity.Methods A total of 80 patients with PD(PD group)admitted to Binhaiwan Central Hospital of Dongguan from November 2020 to January 2022 were selected and divided into mild PD subgroup(n=26),moderate PD subgroup(n=31)and severe PD subgroup(n=23)according to the revised Hoehn-Yahr(H-Y)classification,and 57 healthy sub-jects(control group)were selected during the same period.The differences in serum LncRNA NEATI,and SP1 mRNA expression in each group and their correlation with the H-Y stage were compared.The ROC curve was used to analyze the diagnostic value of the expression of lncRNA NEAT1 and SP1 in PD.Results The serum levels of LncRNA NEAT1 and SP1 mRNA in the PD group were higher than those in the control group(t=6.887,6.303,all P＜0.001).The serum levels of LncRNA NEAT1 and SP1 mRNA in mild,moderate,and severe PD subgroups increased in turn(F=66.803,H=59.259,all P＜0.001).The expressions of serum LncRNA NEAT1 and SP1 mRNA in PD patients were positively correlated with the H-Y stage(rs=0.790,0.840,P＜0.001),and the areas under the curve were 0.787,0.784,and 0.858,respectively.The sensitivity was 58.75％,51.25％and 70.00％,and the specificity was 91.23％,96.49％and 89.47％,respectively.Conclusion The increased expression of serum LncRNA NEAT1 and SP1 mRNA in PD patients is closely related to the progression of the disease,which has a certain diagnostic value for PD,and the combined diag-nostic value is higher.
维普
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