Osteoporosis(OP)is a serious public health problem that affects the quality of life of patients and can lead to fragility fracture.Various studies have shown that OP is closely associated with dysbiosis,which refers to an imbalance of the body's microbiota.Dysbiosis has been linked to a range of systemic diseases,including OP.This paper provides an overview of both fundamental and clinical studies related to flora and OP,summarizing the underlying mechanisms behind alterations in intestinal and oral flora with a specific focus on distinct bacterial species and genera.Bacterial flora affects pathways related to OP pathogenesis by mediating hormonal effects,producing specific metabolites,inducing immune cell differentiation,and altering the levels of inflammatory factors.Different genera have different roles in the pathogenesis of the disease.Lactobacillus,bifidobacterium and fusobacterium in the intestinal flora have protective roles,while Serratia marcescens is a risk factor.TM7 and Lactobacillus in oral flora may have protective effects,and actinomyces and Forses-tanella may promote bone resorptive through inflammatory response.Some genera also play a role in maintaining flora bal-ance.This review aims to provide ideas and references for the treatment of OP by summarizing the connection and interac-tion mechanism between OP and flora.
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