Objective To explore the effect of electrocardiogram(ECG)simulation combined with problem-based learn-ing(PBL)teaching on clinical skills of electrocardiogram on five-year undergraduate students.Methods A total of 138 fourth-year students of 2019 five-year clinical medicine who participated in the training of"Clinical Skills"electrocardio-gram section at the First Affiliated Hospital of the Army Medical University in March 2023 were selected as the research subjects.They were divided into an observation group,a simulation group,and a control group by random drawing meth-od,with 46 participants in each group.The observation group used simulation combined with PBL integrated teaching method,the simulation group only used simulation teaching tools combined with traditional lecture-based learning(LBL)teaching method,and the control group used standardized patient(SP)combined with traditional LBL teaching method.At the end of the course,the implementation effects of the three teaching methods were evaluated through the electrocardi-ogram skill operation,ECG judgment,and questionnaire survey.Results There was no statistical difference in skill op-eration assessment scores among the three groups.However,the ECG diagnostic scores of the observation group were sig-nificantly higher than that of the simulation group and the control group(91.54±3.73 vs.87.78±5.41 vs.86.06±5.25,F=15.290,P<0.001).The questionnaire results showed that the questionnaire results showed that the active learning interest achievement rate of the observation group was higher than that of the control group,and the difference was statisti-cally significant(95.65%vs.78.26%,P<0.05).At the same time,in terms of student evaluation of teaching meth-ods,the observation group had a higher satisfaction rate than the other two groups,and the difference was statistically sig-nificant(97.83%vs.82.61%,P<0.05;97.83%vs.80.43%,P<0.05).Conclusion Compared with the LPL teach-ing method based on SP and simulation tools,the integrated teaching method of simulation and PBL improves the teaching quality of ECG clinical skills,which is helpful to improve medical students'interest in learning electrocardiogram skills and their teaching satisfaction.