Refractory hypertension caused by bilateral renal artery stenosis(RAS)has a low incidence and is difficult to diagnose and treat clinically.The Department of General Medicine of Xuanwu Hospital Capital Medical University admit-ted a 48-year-old male patient with a recent history of severe hypertension.Considering the patient's age and severity of hypertension,we screened for common causes of secondary hypertension.Further abdominal aortic CTangiography showed moderate to severe stenosis at the openings of the bilateral renal arteries,which led to refractory hypertension.Therefore,angioplasty of both renal arteries was performed as a staged procedure,and the patient's blood pressure was gradually controlled and stabilized during postoperative follow-up.This article reviews the specific diagnosis and treatment process and reviews relevant literature.