Objective To establish and validate a nomogram prediction model for vessel re-occlusion after intravenous thrombolysis in acute ischaemic stroke(AIS).Methods A total of 316 patients with AIS who received intravenous thrombolysis at the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from January 2020 to June 2023 were retrospectively analyzed,and divided into non-occlusion group(264 cases)and re-occlusion group(52 cases)according to the status of re-occlusion after intravenous thrombolysis.The differences in clinical characteristics be-tween the two groups were compared,factors affecting vessel re-occlusion were analyzed by multivariate logistic regression and a nomogram model was created.The degree of discrimination and calibration of the model was assessed by using re-ceiver operating characteristic(ROC)and calibration curves,and the clinical decision curve was analyzed.Results Univariate and multivariate logistic regression analysis showed that history of atrial fibrillation,high baseline National In-stitutes of Health Stroke Scale(NIHSS)score and longer time from onset to treatment were risk factors for re-occlusion after intravenous thrombolysis in AIS patients,whereas Tirofiban was protective factor(P＜0.05).The area under ROC curve(AUC)of the constructed nomogram model was 0.768(0.701-0.835).The calibration curve showed that there was good agreement between the prediction of vessel reocclusion by the model and the actual probability of occurrence(Hosmer-Lemeshow x2=8.246,P=0.410).If the risk of vessel re-occlusion after thrombolysis in AIS patients is pre-dicted to be＞0.15 using this model,appropriate interventional measures should be taken.It can make patients get better clinical benefit.Conclusion There are many factors that influence vessel re-occlusion after intravenous thrombolytic therapy in AIS patients,and the reasonably constructed column diagram model has good discriminatory power and accura-cy,which can be used for risk stratification of patients.
Acute ischemic strokeIntravenous thrombolysisReocclusion of blood vesselsInfluencing factor
维普
万方数据
