Objective Corona Virus Disease 2019(COVID-19)has become a global pandemic disease,which can lead to multiple organ damage syndrome and high mortality.Therefore,there is an urgent need for reliable biomarkers that can be used for early screening for possible progression to severe infection,which is important for improving clinical progno-sis.Methods For this retrospective study,basic information and clinical data from December 8,2022 to January 31,2023 were extracted from the medical records of patients with COVID-19 admitted to the 903rd Hospital of the People's Liberation Army.On the basis of a new type of coronavirus infection diagnosis and treatment plan 10(trial version)of parting,after into and exclusion criteria,the patients were divided into two groups,non-severe group(n=57)and severe group(n=37).Univariate analysis was used to screen out statistically significant indicators between the two groups,then multivariate analysis logistic regression was used to screen out independent risk factors affecting the severity of early COV-ID-19.The receiver operating characteristic curve was used to evaluate and analyze the predictive value of the correspond-ing indicators for the severity stratification of COVID-19 in the early stage.Finally,a nomogram was used to evaluate the test efficacy of the prediction model.Results The C-reactive protein/albumin ratio(CRP/ALB),lung consolidation and coronary heart disease were predictors of severity prediction,the area under the ROC of CRP/ALB was 0.762(95％CI:0.663-0.862,P＜0.001),the area under the ROC of lung consolidation was 0.682(95％CI:0.573-0.791,P=0.003),and the area under the ROC of coronary heart disease was 0.638(95％CI:0.520-0.756,P=0.024).The AUC of CRP/ALB and lung consolidation was 0.801(95％CI:0.708-0.894).The nomogram prediction model and its calibration curve showed that the prediction model had high accuracy with the actual situation.Conclusion CRP/ALB combined with lung consolidation can predict the severity of COVID-19.
关键词
新型冠状病毒感染/C反应蛋白与白蛋白的比值/肺实变/严重程度/预测模型
Key words
Corona Virus Disease 2019/The C-reactive protein/albumin ratio/Lung consolidation/Severity/Prediction model
维普
万方数据