Objective To investigate the expression of aldehyde dehydrogenase 8 family member A1(ALDH8A1)in gas-tric cancer tissues and its relationship with clinicopathological parameters,and to analyze its effect on the long-term prog-nosis of patients.Methods A total of 109 patients with gastric cancer who underwent radical resection in the First Affili-ated Hospital of Bengbu Medical University from March 2012 to April 2018 were enrolled.Immunohistochemistry was used to analyze the expression of ALDH8A1 in gastric cancer tissues and adjacent tissues,and statistical methods were used to analyze its relationship with clinicopathological features.Kaplan-Meier Plotter curve was used to analyze the effect of ALDH8A1 expression on the 5-year survival rate of patients with gastric cancer after surgery.Results The expression of ALDH8A1 in gastric cancer tissues was significantly higher than that in adjacent tissues(P＜0.001).The high expres-sion rate of ALDH8A1 was higher in patients with CEA≥5 μg/L,CA19-9≥37 kU/L,adenocarcinoma,T3-4 stage and N2-3 stage(P＜0.05).Kaplan-Meier Plotter curve analysis and multivariate analysis showed that high ALDH8A1 expres-sion(HR=2.674,95％CI:1.293-5.533,P=0.008)may increase the mortality of patients with gastric cancer after surgery.ROC curve showed that with 2.555 as the cut-off value,ALDH8A1 had a high predictive value for the prognosis of gastric cancer patients(sensitivity was 68.97％,specificity was 86.27％).GO and KEGG enrichment analysis showed that ALDH8A1 was related to cell meiosis,DNA binding and cell cycle signaling pathways.Conclusion ALDH8A1 is highly expressed in gastric cancer tissues and promotes the malignant progression of gastric cancer and is as-sociated with poor prognosis.
Gastric cancerAldehyde dehydrogenase 8 family member A1Clinical pathological featuresPrognosis
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