Objective To observe the clinical efficacy,safety,compliance,and vonoprazan fumarate tablet(VPZ)com-bined with amoxicillin capsule for 10 days in the treatment of Helicobacter pylori(Hp)infection.Methods A total of 150 Hp infected patients diagnosed in the Second Affiliated Hospital of Bengbu Medical University from October 2021 to February 2023 were randomly divided into a control group(75 cases)and an experimental group(75 cases)by random number table method.The control group was given esomeprazole magnesium enteric-coated tablets combined with amoxi-cillin capsules,metronidazole tablets,and colloidal bismuth pectin capsules.The experimental group was given the vono-prazan fumarate tablet and amoxicillin capsule.Both groups were treated for 10 days.Hp eradication rate,incidence of adverse reactions,compliance,and cost-effectiveness ratio were compared between the two groups.Results There were 5 cases of shedding in the experimental group and 7 cases in the control group,a total of 12 cases of shedding,70 cases in the experimental group and 68 cases in the control group.According to the protocol(PP)analysis,the eradication rates of Hp in the experimental group and control group were 91.43％(64/70)and 83.82％(57/68),respectively,with no statistical significance(P=0.174).According to intention-to-treat(ITT)analysis,the eradication rates of the experimental group and control group were 85.33％(64/75)and 76.00％(57/75),respectively,with no statistical sig-nificance(P=0.148).The incidence of adverse reactions in the experimental group and the control group was 4.29％(3/70)and 14.71％(10/68),respectively,and the difference was statistically significant(P＜0.05).The compliance of the experimental group and the control group was 97.14％(68/70)and 88.24％(60/68),respectively,with no sta-tistical significance(P=0.091).The cost-effectiveness ratio of the experimental group and the control group were 2.22 and 3.64,respectively.Conclusion Compared with esomeprazole magnesium enteric-coated tablet combined with two antibiotics and bismuth,Vonolazan fumarate tablet combined with one antibiotic in the radical treatment of Hp infection patients has the same clinical efficacy,high safety and benefit,and good compliance,which is worthy of clinical promo-tion.
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