Objective Based on the theory that microRNA-134(miR-134)and microRNA-16(miR-16)are involved in the gene regulation process of depression,this paper analyzes the effects of two factors in serum on the one-year recur-rence risk of patients with first-episode depression who stopped taking selective serotonin reuptake inhibitors(SSRIs)during the consolidation period.Methods A total of 125 patients with first-episode depression who were treated with 5-hydroxytryptamine reuptake inhibitors and stopped during the consolidation period from October 2021 to May 2022 in Sha-oxing Seventh People's Hospital were selected.Kaplan-Meier survival analysis and Cox proportional hazard regression model were used to evaluate the effect of serum miR-134 and miR-16 on one-year recurrence after withdrawal.Results K-M survival analysis showed that the distribution of the"non-recurrent state"in patients with high serum miR-134 and miR-16 levels was(11.01±0.27)months and(11.14±0.29)months,respectively.This was significantly longer than that in patients with low serum miR-134[(9.32±0.42)months]and miR-16[(9.59±0.36)months,with P＜0.05].Cox analysis showed that family history of depression was the risk factor for one-year recurrence(HR=2.219).The pro-tective factors included prolonged medication time(HR=0.759),elevated serum level of miR-134(HR=0.005),ele-vated level of miR-16(HR＜0.001),and combined physical therapy(HR=0.188).Conclusion The expression levels of serum miR-134 and miR-16 have a good preventive and protective effect on the recurrence of first-episode depression patients after stopping SSRIs for one year in consolidation period.
维普
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