首页|中性粒细胞与淋巴细胞比值辅助诊断老年社区获得性尿路感染的研究

中性粒细胞与淋巴细胞比值辅助诊断老年社区获得性尿路感染的研究

Diagnostic value of neutrophil-to-lymphocyte ratio in elderly patients with community-acquired urinary tract infection

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目的 探究中性粒细胞计数与淋巴细胞计数比值(NLR)在早期辅助诊断老年社区获得性尿路感染中的价值,为基层临床医生诊治尿路感染提供依据.方法 选取2012年1月-2022年12月首都医科大学宣武医院老年社区获得性尿路感染患者159例(感染组),根据是否进展为血流感染分为尿源性血流感染组(28例)和尿路感染非血流感染组(131例),同时选取同时间段,年龄≥60岁,因非感染疾病入院的患者172例(非感染组).采用ROC曲线分析NLR对社区获得性尿路感染的临床诊断价值.结果 NLR辅助诊断老年社区获得性尿路感染的AUC为0.729,最佳阈值、灵敏度、特异度分别为3.5、60%、84%.NLR辅助诊断老年社区获得性尿路感染非血流感染的AUC为0.684,最佳阈值、灵敏度、特异度分别为3.7、47%、90%.NLR辅助诊断老年社区获得性尿路感染血流感染的AUC为0.935,最佳阈值、灵敏度、特异度分别为6.0、86%、99%.结论 (1)NLR对老年社区获得性尿路感染有诊断价值,当NLR≥6.0时,应结合临床表现,警惕进展为血流感染,及时转诊上级医院.(2)尿路感染病原菌以革兰阴性菌为主,最常见的为大肠埃希菌,因此,可根据病原菌分布特点及早干预.
Objective To investigate the value of the neutrophil to lymphocyte ratio(NLR)in the diagnosis of communi-ty-acquired urinary tract infection in the elderly.Methods A total of 159 elderly patients with community-acquired uri-nary tract infection(infection group)were selected from Xuanwu Hospital of Capital Medical University from January 2012 to December 2022.According to whether they progressed to bloodstream infection,they were divided into uro-de-rived bloodstream infection group(28 cases)and non-bloodstream infection group(131 cases).A total of 172 inpatients were matched for non-infectious diseases during the same period(non-infected group).ROC curve was used to analyze the clinical diagnostic value of NLR in community acquired urinary tract infection.Results The AUC of NLR was 0.729,and the optimal threshold,sensitivity and specificity were 3.5,60%and 84%,respectively.The AUC of the non-bloodstream infection group was 0.684,and the optimal threshold,sensitivity and specificity were 3.7,47%and 90%,respectively.The AUC of NLR in the diagnosis of community-acquired urinary tract infection in the elderly was 0.935,and the optimal threshold,sensitivity and specificity were 6.0,86%and 99%,respectively.Conclusion(1)NLR has diagnostic value for community-acquired urinary tract infection in elderly people.When NLR ≥ 6.0,the patient should be vigilant of progressing to bloodstream infection according to clinical manifestations and be referred to su-perior hospital in time.(2)The main pathogens of urinary tract infection are gram-negative bacteria,the most common of which is Escherichia coli.Therefore,early intervention can be performed according to the distribution characteristics of the pathogens.

Neutrophil to lymphocyte ratioDiagnosisUrinary tract infectionCommunity-acquiredThe elderly

裴倩倩、高云、王春梅

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航天中心医院全科医学科,北京 100049

首都医科大学宣武医院重症医学科,北京 100053

中性粒细胞与淋巴细胞比值 诊断 尿路感染 社区获得性 老年

国家重点研发计划项目国家重点研发计划项目首都全科医学研究专项项目

2020YFC20054032020YFC200540621QK08

2024

中华全科医学
中华预防医学会,安徽省全科医学会

中华全科医学

CSTPCD
影响因子:1.688
ISSN:1674-4152
年,卷(期):2024.22(7)